Skip to Content

Heart Transplant Process at University of Colorado Hospital

The heart transplant process at University of Colorado Hospital follows established best practices for organ transplantation and patient recovery.

Preliminary Evaluations

Before you receive a heart transplant, you will undergo a series of tests to determine your current health.

After these tests are performed, various members of the heart transplant medical team will give you a thorough evaluation.

Following your tests and evaluation, a cardiologist presents your case to the Patient Selection Committee for Heart Transplantation. The committee, which meets weekly, is made up of transplant program doctors, surgeons, nurse coordinators, social workers, clergy and psychiatrists. They determine whether a heart transplantation is a safe procedure for you. They also will discuss an optimal plan of care for you after transplantation.

Your transplant coordinator will inform you of the committee’s decision and plan.

Once you are accepted for transplant, your information is entered on the active heart transplant waiting list (see below), and the search for a new heart for you begins.

Screening While on the Waiting List

Please note that every patient on the waiting list may be randomly screened for drugs or alcohol at any time.

The screening test may be done using a blood or urine sample. Anyone who tests positive for alcohol or illegal drugs will be removed from the waiting list.

Your Heart Transplant Surgery

After you have received a call to come to the hospital for your transplant surgery, you are admitted to the transplant unit. This is where preparation for surgery begins.

Upon arrival to the transplant center you will:

  • Meet with your doctors and surgeons
  • Sign one or more consent forms
  • Have a few routine tests such as chest X-ray, EKG and blood draw
  • Be given medications important for the success of your transplant

Your surgery will not begin until the donor heart:

  • Arrives at the hospital
  • Is examined by the transplant surgeon
  • Is considered to be acceptable

Once the decision to proceed with the surgery has been made, you will be given an anesthetic to put you to sleep for the surgery.

Heart transplant surgery can be divided into four stages:

  • Transfer of heart and lung function to bypass machine
  • Removal of the old heart
  • Replacement with the new heart
  • Removal from bypass machine

Although there are several factors that may influence the difficulty of your surgery, the operation should last three to four hours.

Summary of procedure

An incision or cut is made in your chest. Special tubes are placed to connect you to a bypass machine. This machine does the work of your heart and lungs during the transplant. Your old heart is removed and replaced with the new organ. You will be disconnected from the bypass machine and your new heart will be connected to a pacer box and begin beating. The pacer box will control your heart rate and is usually only needed for a few days after surgery.

After Your Heart Transplant Surgery

After your surgery you will be taken to a private room in the Intensive Care Unit (ICU) for recovery. Your stay in the ICU will usually last three to five days, but may be longer depending on your condition.

From the ICU, you will go to room in a specialized transplant unit. Here you will begin a closely monitored recovery process. You and your family will participate in various education sessions about your medication, diet, activities and follow-up care. Barring any complications, your stay in the unit usually lasts five to ten days.

Monitoring Your Recovery After Your Procedure

Members of your medical team will monitor you closely for the first several months after you leave the hospital.

Initially, you will need to return for appointments and procedures two to three times a week for about one month. Visits will continue once a week for the next three months.

For the first month after transplant, you will have weekly heart biopsies. The biopsy is done by removing small pieces of the heart to be examined under a microscope for signs of rejection. The biopsies are not painful and only require numbing medication. As time passes these biopsies become less frequent. Eventually they will only be done every four to six months.

Long-term medical follow-up is extremely important so that any problems can be detected early and treated promptly. Common post-transplant problems may include:

  • Rejection
  • Infection
  • Hypertension (high blood pressure)
  • Coronary artery disease (blockages in the heart vessels)

Regular blood tests, biopsies and examinations help your doctors detect these problems early.

You will receive a complete list of symptoms that may be a sign of a problem. It's important that you report any signs to your transplant team immediately.

If you live outside the Denver area, your transplant coordinator will arrange for your long-term follow-up care to be managed by your local doctor and lab facility.

Diet and Exercise After Your Transplant

You will begin a diet and exercise plan while in the hospital, and you should continue that plan upon returning home. Following the plan is very important in regaining and maintaining day-to-day activities.

Your exercise plan is a step-by-step process:

  • Sitting up and standing
  • Walking in the hospital (as long as your biopsies are normal)
  • Home walking program (you will be given an eight week walking schedule to follow as long as biopsies are normal)
  • Walking is the most highly recommended form of exercise, but treadmills, bicycles or other equipment can be added slowly into your exercise program.
  • Your breastbone will take six to eight weeks to heal. During this time you should not lift anything heavier than 10 pounds.

Benefits of exercise. Exercise for transplant patients has been shown to:

  • Increase endurance
  • Increase muscle strength
  • Enhance bone remodeling
  • Reduce the need for anti-hypertension medication

Proper nutrition. Proper nutrition also is critical for post-heart transplant patients. Certain medications you may take will affect the way your body processes food. You will receive medication guidelines related to your diet.

Your dietitian at the hospital will help you create meal plans that are both nutritious and low in calories. Following your diet is important in the total rehabilitation process, and for maintaining good health throughout your life with your new heart.


Learn more about the heart transplant waiting list

Typically, patients who are selected as candidates for heart transplantation wait some time for a healthy, viable donor heart to become available. Here's what determines how long their wait might be.

The UNOS system

The University of Colorado Hospital Heart Transplant Program follows the United Network for Organ Sharing (UNOS) system for prioritizing heart transplant candidates. UNOS is a nationwide network supervised by the federal government to help ensure that all patients receive healthy organs as soon as they become available. All transplant centers in the United States belong to UNOS.

For this system to work, it relies on organ procurement organizations, called OPOs. OPOs match and distribute donated organs, 24 hours a day, 365 days a year.

Donor Alliance The OPO in our region is Donor Alliance (DA).

DA is responsible for the coordination, retrieval and distribution of organs in Colorado and Wyoming.

Donor matching criteria

The process of matching donor organs to patients awaiting transplant is based on many criteria to make sure patients are stable and prepared, including:

  • Medical urgency of the transplant candidate
  • Time spent on the waiting list
  • Biologic compatibility (organ size, blood type, etc.)
  • The candidate’s ability to be transplanted immediately

If all candidates are of similar degrees of illness, then it is offered to the person with the longest waiting time.

Donated organs are distributed locally first. If no suitable match exists in the local area, the organ is offered regionally and then nationally.

During the waiting period, you will be monitored by your cardiologist. Your cardiologist will keep the transplant surgeon and coordinator informed about changes in your condition.

If you live far away from University of Colorado Hospital, your care may be managed by your primary care doctor. However, it is important that you are seen monthly by a transplant center cardiologist. You also will be given guidelines about diet and exercise.

Request an Appointment