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Factor XII (Hageman factor) deficiency
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Factor XII (Hageman factor) deficiency

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Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting.

When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.

Factor XII is one such factor. A lack of this factor does not cause you to bleed abnormally. But, the blood takes longer than normal to clot in a test tube.

Factor XII deficiency is a rare inherited disorder.

I Would Like to Learn About:

  • Causes

    When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.

    Factor XII is one such factor. A lack of this factor does not cause you to bleed abnormally. But, the blood takes longer than normal to clot in a test tube.

    Factor XII deficiency is a rare inherited disorder.

  • Symptoms

    There are usually no symptoms.

  • Exams and Tests

    Factor XII deficiency is most often found when clotting tests are done for routine screening.

    Tests may include:

    • Factor XII assay
    • Partial thromboplastin time (PTT)
    • Mixing study
  • Treatment

    Treatment is usually not needed.

  • Outlook (Prognosis)

    The outcome is expected to be good without treatment.

  • Possible Complications

    There are usually no complications.

  • When to Contact a Medical Professional

    The health care provider usually discovers this condition when running other lab tests.

  • Prevention

    This is an inherited disorder. There is no known way to prevent it.

Related Information

     

References

Gailani D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 139.

Ragni MV. Hemorrhagic disorders: coagulation deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 177.

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Review Date: 1/22/2015  

Reviewed By: Rita Nanda, MD, assistant professor of medicine, section of hematology/oncology, University of Chicago Medicine, Chicago, IL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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