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Health Information

Clopidogrel (Plavix)

Clopidogrel (Plavix)


Blood thinners - clopidogrel; Antiplatelet therapy - clopidogrel

Taking clopidogrel helps prevent blood clots from forming in your arteries. This medicine helps reduce your risk of stroke or heart attack.

Clopidogrel may be used to:

  • Prevent or treat heart attacks
  • Prevent stroke or transient ischemic attacks (TIAs -- early warning signs of stroke, also called "mini-strokes")
  • Increase blood flow to your legs
  • Prevent clots from forming inside stents put inside your arteries to open them

This medicine is taken as a pill. Your doctor may change your dose from time to time.

I Would Like to Learn About:

  • Side Effects

    Side effects of this medicine may include:

    • Diarrhea
    • Itching
    • Nausea
    • Skin rash
    • Stomach pain

    Before you start taking clopidogrel, tell your health care provider if:

    • You have bleeding problems or stomach ulcers.
    • You are pregnant, plan to become pregnant, or are breastfeeding.
  • Taking Clopidogrel

    Take this medicine with food and plenty of water to reduce side effects. You may need to stop taking clopidogrel before you have surgery or dental work. Do NOT just stop taking your medicine without first talking with your health care provider.

    Talk with your provider before taking any of these drugs:

    • Heparin and other blood thinners, such as warfarin (Coumadin)
    • Pain or arthritis medicine (such as diclofenac, etodolac, ibuprofen, indomethacin, Advil, Aleve, Daypro, Dolobid, Feldene, Indocin, Motrin, Orudis, Relafen, or Voltaren)
    • Phenytoin (Dilantin), tamoxifen (Nolvadex, Soltamox), tolbutamide (Orinase), or torasemide (Demadex)

    Do not take other drugs that may have aspirin or ibuprofen in them before talking with your provider. Read the labels on cold and flu medicines. Ask what other medicines are safe for you to take for aches and pains, colds, or the flu.

    Tell your provider if you are pregnant or planning to become pregnant, or breastfeeding or planning to breastfeed. Women in the later stages of pregnancy should not take clopidogrel. Clopidogrel can be passed to infants through breast milk.

    If you miss a dose:

    • Take it as soon as possible, unless it is time for your next dose.
    • If it is time for your next dose, take your usual amount.
    • Do NOT take extra pills to make up for a dose you have missed, unless your doctor tells you to.

    Store these drugs and all other medicines in a cool, dry place. Keep them where children cannot get to them.

  • When to Call the Doctor

    Call if you have any of these side effects and they do not go away:

    • Any signs of unusual bleeding, such as blood in the urine or stools, nosebleeds, any unusual bruising, heavy bleeding from cuts, black tarry stools, coughing up blood, heavier than usual menstrual bleeding or unexpected vaginal bleeding, vomit that looks like coffee grounds
    • Dizziness
    • Difficulty swallowing
    • Tightness in your chest or chest pain
    • Swelling in your face or hands
    • Itching, hives, or tingling in your face or hands
    • Wheezing or difficulty breathing
    • Very bad stomach pain
    • Skin rash

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Review Date: 8/12/2014  

Reviewed By: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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